Anti N-methyl-D-aspartate receptor encephalitis:A case series from Myanmar

[摘要] Objectives: Since 2007, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has beenincreasingly reported worldwide. Although the diagnostic testing of anti-NMDAR encephalitis wasavailable in Myanmar since 2016, there have been no studies reported so far. This is a report of antiNMDAR encephalitis admitted to one of the tertiary care hospitals in Myanmar. Methods: It is anobservational study of anti-NMDAR encephalitis admitted at North Okkalapa General and TeachingHospital (NOGTH) for three consecutive years. Results: In this study, ten patients diagnosed as antiNMDAR encephalitis were included. Median age of onset was 21 years, ranged from 16 to 85 years.Nine out of ten patients were female (90%). Seven patients (70%) showed four of the six major groupsof symptoms. Only one patient (10%) was found to have ovarian teratoma. EEG abnormalities wereobserved in all patients (100%). Out of six MRIs done, four (66.6%) were normal.Conclusion: This study showed that demographic profile, clinical characteristics, and ancillary testresults were in similarity with other previous studies but mortality rate of 40% was relatively highas compared to previous studies.

[学科分类] 精神健康和精神病学

[关键词] Anti-NMDAR-encephalitis;teratoma;delta brush;Myanmar;psychotic;hyperkinetic;plasma exchange