Current management of Barrett esophagus and esophageal adenocarcinoma

[摘要] Barrett esophagus is found in 5% to 15% of patientswith gastroesophageal refl ux disease and is a precursorof esophageal adenocarcinoma, yet the condition oftengoes undiagnosed. Patients with refl ux disease who aremale, over age 50, or white, and who smoke or havecentral obesity or a family history of Barrett esophagusor esophageal adenocarcinoma, should undergo initialscreening endoscopy and, if no dysplasia is noted, surveillance endoscopy every 3 to 5 years. Dysplasia is treatedwith endoscopic eradication by ablation, resection, orboth. Chemoprotective agents are being studied to prevent progression to dysplasia in Barrett esophagus. Theauthors discuss current recommendations for screeningand management.

[学科分类] 卫生学