Pituitary injury and persistent hypofunction resulting from a peripartum non-hemorrhagic, vaso-occlusive event
[摘要] Cerebral vascular accidents are caused by vasospasm when induced by preeclampsia or by dopamine agonists. However,six arteries nourish the pituitary and prevent against vasospasm-induced damage, which up until now has not been thoughtto occur. Bromocriptine was used to arrest lactation in a 31-year-old with secondary amenorrhea following preeclampsia andfetal demise at 28 weeks gestation. Tests and history revealed panhypopituitarism not associated with hemorrhage or massinfarction but instead caused by vasospasm. The present study is the first report of pituitary damage from a nonhemorrhagic, vaso-occlusive event in the literature. In keeping with Sheehan’s and Simon’s syndromes, we have namedpituitary damage resulting from vaso-occlusion as Dahan’s syndrome, and a literature review suggests that it may be acommon and previously overlooked disorder.
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[效力级别] [学科分类] 血液学
[关键词] Adult;Female;Black - other;Canada;Pituitary;Pituitary;Cortisone;Pituitary apoplexy;Hypopituitarism;Panhypopituitarism;Pregnancy;Pre-eclampsia;Diabetes mellitus type 2;Infertility;Fetal demise;Intracranial vasospasm;Amenorrhoea;Headache;Hemiparesis;Infertility;Hypoprolactinaemia;CT scan;Angiography;Haemoglobin A1c;FSH;LH;Oestradiol (E2);FT4;Testosterone;Prolactin;IGF1;Clomid challenge;MRI;Cortisol;Dopamine agonists;Insulin;Glucocorticoids;Cortisol;Gynaecology;Obstetrics;Radiology/Rheumatology;New disease or syndrome: presentations/diagnosis/management;June;2015 [时效性]
