Thyrotoxicosis with absence of clinical features of acromegaly in a TSH- and GH-secreting, invasive pituitary macroadenoma
[摘要] A 54-year-old woman presented with bi-temporal hemianopia, palpitations, and diaphoresis. An invasive pituitarymacroadenoma was discovered. The patient had biochemical evidence of secondary hyperthyroidism and GH excess;however, she did not appear to be acromegalic. Surgical removal of the pituitary mass revealed a plurihormonal TSH/GHco-secreting pituitary adenoma. TSH-secreting adenomas can co-secrete other hormones including GH, prolactin, andgonadotropins; conversely, co-secretion of TSH from a pituitary adenoma in acromegaly is infrequent.
[发布日期] [发布机构]
[效力级别] [学科分类] 血液学
[关键词] Adult;Female;White;United States;Pituitary;Pituitary;TSH;GH;Pituitary adenoma;Plurihormonal pituitary adenoma;Hemianopia;Hirsutism;Palpitations;Hot flushes;Sweating;Obesity;MRI;Thyroid function;Total T4;Total T3;FT4;TSH;IGF1;GH;Prolactin;Cortisol (serum);ACTH stimulation;Immunohistochemistry;Transsphenoidal surgery;Octreotide;Methimazole;Surgery;Unique/unexpected symptoms or presentations of a disease;January;2015 [时效性]
