Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3

[摘要] Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene ( PML ) at 15q22 with the retinoic acid α-receptor gene ( RARA ) at 17q21. We generated an induced pluripotent stem cell line “KUMi003-A” from an APL M3 patient that is pluripotent and can differentiate into the three germ layers. This iPSC line will be useful as a disease model to investigate disease mechanisms specific to APL M3.

[学科分类] 生理学