Generation and characterisation of four multiple sclerosis iPSC lines from a single family

[摘要] Multiple sclerosis (MS) is a complex neuroinflammatory/degenerative disease of the central nervous system (CNS) that results in the formation of demyelinated lesions and axon degeneration. MS aetiology is complex, with genetics estimated to account for ∼48% of MS risk ( International Multiple Sclerosis Genetics Consortium, 2019 ). Despite this, families with a high incidence of MS are rare. We have generated four induced pluripotent stem cell (iPSC) lines from individuals with relapsing-remitting and secondary progressive MS within a single family. The generation of disease-specific iPSC lines from multiple members of a single family will facilitate MS genetic and functional studies.

[学科分类] 生理学

[关键词] Induced pluripotent stem cells;Multiple sclerosis;Neurodegenerative disease;Reprogramming