Toxicoepigenetics for Risk Assessment: Bridging the Gap Between Basic and Regulatory Science

[摘要] Cytologically visible constitutive heterochromatin found at thecentromeric and telomeric regions of chromosomes representsthe largest differentiated chromatin compartment in eukaryotic nuclei.1 Outside constitutive heterochromatin, heterochromatin-like domains (HLD, >.1Mb) and complexes(HLC, <.1Mb) are found along the chromosome arms.2HLD/Cs are present in eukaryotic genomes as divergent as fission yeast and human, with expansions in size and number inmammals. In human, there are ~163 to 859 HLDs and ~18853to 32292 HLCs, depending on cell type.2 Some of the largestHLDs are the KRAB-ZNF HLDs on chromosome 19.Notably, contacts among these large HLDs emerge as the heterochromatic B4 sub-compartment in Hi-C maps.

[学科分类] 兽医学

[关键词] Heterochromatin;HP1;Hi-C;H3K9me3;phase separation