Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study

[摘要] Background: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP inyoung persons have been suggested to decrease the risk of multiple sclerosis (MS).Objectives: To assess CRP as a risk factor for MS.Methods: Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837individuals who later developed MS and 984 matched controls. The risk of developing MS was analysedby conditional logistic regression on z-scored CRP values.Results: Levels of CRP were not associated with MS risk.Conclusions: We found no association between CRP levels and risk of MS development.

[关键词] Case-control studies;C-reactive protein;systemic inflammation;multiple sclerosis