Where do plasmacytoid dendritic cells find the energy?

[摘要] Immunometabolism has entered center stage over the last decadeas a critical component of understanding the immune responseto pathogens and self-antigens.1 A clearer understanding of themetabolic reprogramming that occurs in innate and adaptive cell typesto impact activation state, cytokine and chemokine production, and differentiation is emerging. However, plasmacytoid dendritic cells (pDCs)have been highly understudied in this regard and it is not clear that thedeveloping framework of immunometabolism can be generalized tothis cell type. Reports to date have not come to a consensus regardingthe metabolic pathways that are at play in regulating the primary roleof pDCs: production of type I IFN. In this report, Hurley et al. bring pDCbiology into the newly developing field of immunometabolism. Specifically, they identify the metabolic reprogramming that facilitates rapidtype I IFN production following activation via viral genomic material.

[学科分类] 生理学