Antimicrobial zinc toxicity in Mϕs: ZnT1 pays the toll

[摘要] Transition metals, including zinc, are essential to all living organisms. They are also toxic in high amounts, and their intracellular concentration must be tightly regulated. In this edition of JLB , Stocks et al. report that the zinc transporter, ZnT1 (SLC30A1) is induced by TLR4 activation in Mϕs, in which it contributes to zinc accumulation in Escherichia coli -containing phagosomes, resulting in increased bacterial clearance.

[学科分类] 生理学