Emerging neutrophil plasticity: Terminally differentiated cells no more

[摘要] Immune cells have evolved as highly plastic cells that can adapt tochallenges and environmental cues and in the process acquire newfunctional phenotypes. This flexible malleable adaptation is critical formaintaining tissue homeostasis and cellular function in health and disease. Such concepts are exemplified by the well-recognized CD4 cellular plasticity, which is required for maintenance of immunocompetence, or M? plasticity and phenotypic switch, which defines initiation and resolution of inflammation and tissue regeneration.1 Here wewill discuss the emerging phenotypical and functional plasticity of neutrophils (PMNs).

[学科分类] 生理学