Stabilizing the immune system by chlorogenic acid

[摘要] It has been suggested that CGA can control glucose, amino acid, andlipid metabolism1,2. In a mouse model of DSS-induced ulcerative colitis,CGA reduced mucosal damage, suppressed inflammation and oxidativestress, and reduced expression of components of the MAPK/ERK/JNKsignaling pathways.3 Human macrophages respond to the CGA fromthe Nelumbo nucifera (Indian lotus) extract by the suppression of NFκB-dependent inflammatory response and by the decreased production of TNFalpha.2 In human endothelial cells, CGA enhanced sirtuin 1(SIRT1) deacetylase activity and reversed oxLDL-impaired SIRT1 activity, mitigated oxLDL-induced oxidative stress and dysfunction of mitochondrial biogenesis.4 Silencing SIRT1, AMPK, and PGC-1 diminishedthe ability of CGA to protect cells against oxidative stress, indicatingthat CGA inhibits oxLDL-induced endothelial apoptosis through modulating SIRT1 and AMPK/PGC-1 function in the vasculature.

[学科分类] 生理学

[关键词] Chlorogenic Acid;macrophage;pneumonia;sirtuin;sodium-glucose cotransporter