IgG4-related inflammatory pseudotumor involving the temporal bone disguised as meningioma: a case description and literature analysis

[摘要] In 2003, immunoglobulin G4 (IgG4)-related disease(IgG4-RD) was identified as a unique disease (1).Fibroinflammatory lesions caused by IgG4-RD can mimica tumor and affect nearly any organ, including the lacrimalglands, orbits, pancreas, bile ducts, major salivary glands,renal tubules, bones, lungs, aorta, pachymeninges, andthyroid gland (2,3). IgG4-RD is characterized pathologicallyby the presence of lymphoplasmacytic infiltration, storiformfibrosis, obliterative phlebitis, and prominent IgG4-positive plasma cell infiltrates (4). Nearly 20% of patientswith IgG4-RD often have normal concentrations of serumIgG4 (5). A wide range of IgG4-RD lesions has been foundto affect the temporal bone, including space-occupyinglesions that cause cranial nerve palsies and locally invasivelesions that cause bony destruction (6). IgG4-RD lesionsmust also be differentiated from benign and malignanttumors involving the temporal bone, such as hemangioma,meningioma, cancer, and lymphoma. Furthermore, IgG4-related neurological disease symptoms frequently resembletumors, infections, and other inflammatory disorders. Here,we present a rare case of an IgG4-related inflammatorypseudotumor in the temporal bone that resembled ameningioma and discuss the relevant literature for reviewingthe symptoms, treatment, and prognosis of the disease.

[学科分类] 外科医学