Magnetic resonance spectroscopy and gadolinium enhancement assist in the diagnosis of nonalcoholic Marchiafava-Bignami disease with necrosis lesions: a case description

[摘要] Marchiafava-Bignami disease (MBD) is a severeneuropsychiatric disorder characterized by demyelination,necrosis, and cystic changes of the corpus callosum (CC)(1,2). Common symptoms include an altered mentalstate, impaired memory, disorientation, and seizures (1).MBD has been frequently associated with chronicalcoholism in the literature, and is easily overlooked andmisdiagnosed in an environment of other malnutritionpredisposing conditions, such as gastritis and anemia (3).Noncontrast head computerized tomography has revealedsymmetrical hypodensity lesions of the CC, and cerebralmagnetic resonance imaging (MRI) has shown symmetricalhyperintensity of the CC on T2-weighted images (T2WI)and fluid-attenuated inversion recovery (FLAIR) images,and hypointensity on T1-weighted images (T1WI), withor without extra-callosal lesions (1). CC lesions of MBDdo not have a mass effect, and there is a classic sandwichsign due to central demyelination or necrosis of the CCand sparing of the dorsal and ventral layers (4). The CClesions eventually improve completely or become wellcircumscribed cavitations (4).

[学科分类] 外科医学