Let's not blame cocaine as a cause of rhabdomyolysis until all other causes have been ruled out

[摘要] We read with interest the article by Lugo-Fagundo et al. about a 56-year-old male with rhabdomyolysis in whom the condition was diagnosed by muscle computed tomography (CT) [1]. His previous history was positive for polytoxicomania [1]. The study is appealing but raises concerns that should be discussed. Rhabdomyolysis is usually diagnosed upon the clinical presentation and blood chemical values. Patients complain about tiredness, myalgia, cola-colored urine, and urinary retention. Clinical exam may reveal muscle weakness, reduced tendon reflexes, sore muscles, swelling, and stiffness. Blood tests may show elevated muscle enzymes, particularly creatine-kinase (CK) of five times the upper limit, myoglobinemia, myoglobinuria, hypocalcemia, hyperkaliemia, and renal insufficiency.

[学科分类] 生物化学工程

[关键词] mtDNA;m.3243A>G;Epilepsy;Status Epilepticus;Phenotype