Adoptive Transfer of Autologous Invariant Natural Killer T Cells as Immunotherapy for Advanced Hepatocellular Carcinoma: A Phase I Clinical Trial

[摘要] Lessons Learned Administration of autologous invariant natural killer T (iNKT) cells was safe and well-tolerated in patients with hepatocellular carcinoma (Barcelona Clinic Liver Cancer stage B/C). Expanded iNKT cells produced T-helper 1–like responses with possible antitumor activity. No severe adverse events were observed in any of the enrolled patients, including one patient who received 10 10 in vitro–expanded autologous iNKT cells as a single infusion.

[学科分类] 地质学

[关键词] Hepatocellular carcinoma;Natural killer T cells;Immunotherapy