CANOMAD unmasked by COVID-19 in a man with Waldenström's macroglobulinaemia

[摘要] CANOMAD is a rare syndrome encompassing chronic ataxic neuropathy, ophthalmoplegia, IgM paraprotein, cold agglutinins and disialosylantibodies [1,2]. We present a case of acute craniobulbar palsy associated with COVID-19 in which the combination of an established IgMparaprotein and the later emergence of a typical and persistent ganglioside antibody profile ultimately revealed a diagnosis of CANOMADsyndrome.We review the clinical presentation, diagnostic work-up andcurrent treatment.

[关键词] cold agglutinin;immunoglobulin;neuropathy;WM