Intravascular clusters of T cells following chimeric antigen receptor T cell therapy

[摘要] A 52-year-old male was diagnosed with diffuse large B-cell lymphoma(DLBCL) with BCL2, BCL6, and MYC translocations (triple hit lymphoma). In addition to nodal, splenic, and gingival lesions, bone marrow was extensively involved with lymphoma cells (up to 90% of the nucleated cells). Although he received eight cycles of dose-adjusted (DA)-EPOCH-R (etoposide, prednisolone, vincristine, cyclophosphamide,doxorubicin, and rituximab), his lymphoma recurred shortly after thecompletion of planned therapy. His disease was not controlled by additional three lines of chemotherapy, but as there seemed no other effective treatment options, he proceeded to tisagenlecleucel therapy at hisown wish.