Cutaneous cryptococcosis in a patient with myelofibrosis receiving JAK-inhibitor

[摘要] A 75-year-old woman diagnosed of post-polycythemia vera myelofibrosis (post-PV MF) with JAK2V617F mutation 11 years ago presentedwith two protruding, reddish, easily bleeding mass lesions over herleft abdominal surface for 2 months (Figure 1). The lesions gradually enlarged to the size of 8 × 6 cm2 and 6 × 2 cm2, and progressed withpain and ulceration. Over the past 4 years, she received ruxolitinibtreatment for MF-related constitutional symptoms and splenomegalywith good control. Laboratory testing showed a white-cell count of7650 per cubic millimeter with 42% neutrophils and 5% blasts.