Massive eosinophilia despite severe aplastic anemia

[摘要] A 47-year-old nonsmoking man developed very severe aplastic anemia (AA) (hemoglobin 56 g/L, neutrophils 110/μl, eosinophils 0/μl,platelets 4000/μl) with fatty marrow (Figure 1A: hematoxylin–eosin stain, ×4 objective). He had a history of bronchial asthma for 3 yearsand had been treated with inhaled corticosteroid in combination withlong-acting β2-agonist (budesonide/formoterol fumarate). In addition,he had developed eosinophilic pneumonia requiring systemic administration of prednisolone (<30 mg/day) twice in the last 1.5 years.