Osteolytic lesion in polycythemia vera: First report and review of literature

[摘要] Myeloproliferative neoplasms (MPNs) are a group of rare clonal disorders of hematopoietic progenitor cells that are associated with morbidity from disease-related symptoms, thrombotic events, and risk oftransformation to acute myeloid leukemia (AML) [1]. The three mostcommon MPNs are polycythemia vera (PV), essential thrombocytosis(ET), and myelofibrosis (MF). Patients with MPN can experience a constellation of debilitating symptoms that negatively impact their qualityof life [2–5]. In prior surveys of patients with MPNs, bone pain was thefourth most common symptom reported by 44% of patients and ratedas “very severe” in up to a third of MF patients [2–5].In very rare situations, patients with MPN can develop osteolyticlesions [6–21]. We report the first case of an osteolytic lesion in achronic-phase PV patient, and review published case reports of MPNpatients with osteolytic lesions to summarize the clinical characteristics and implications for patient care.

[关键词] bone pain;myeloproliferative neoplasms (MPNs);osteolytic lesion;polycythemia vera