Long-term outcome of immunologic autograft engineering

[摘要] Our phase III trial reported that autograft-absolute lymphocyte count (A-ALC) improved survival post-autologous peripheral blood hematopoietic stem cell transplantation (APBHSCT) for a short-term follow-up of 2 years. We evaluated retrospectively in our phase III trial patients that the A-ALC still confers survival benefit with a longer follow-up. With a median follow-up of 127.6 months, patients infused with an A-ALC ≥ 0.5 × 10 9 cells/kg experienced better overall survival (HR = 0.392, 95% confidence of interval [CI]: 0.224–0.687, p  < 0.001) and progression-free survival (HR = 0.413, 95% CI: 0.253–0.677), p  < 0.0004). This study supports that A-ALC provides long-term survival benefit post APBHSCT.

[关键词] autograft absolute lymphocyte count;autologous peripheral blood hematopoietic stem cell transplantation;survival