Proposal of ‘reactive-lymphocyte/histiocyte rich large B-cell lymphoma’ as an alternate term for ‘nodular lymphocyte predominant Hodgkin lymphoma’ that would also address its overlap with T-cell/histiocyte rich large B-cell lymphoma

[摘要] In the WHO classification, Hodgkin lymphoma is broadly classifiedas nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) andclassic Hodgkin lymphoma (CHL) [1].While this approach has served uswell for many years, there is renewed thinking as to whether ‘NLPHL’should be excluded from Hodgkin lymphoma. The reasoning comesfrom – (1) the overlap and biological relatedness to T-cell/histiocyterich large B-cell lymphoma (THRLBCL); and (2) the distinctiveness ofthe neoplastic cells of NLPHL from CHL [2]. If these reasons are valid,what would be the appropriate term that would address the issues andcapture the characteristic features.