Thromboembolic hazard in hereditary hemorrhagic telangiectasia

[摘要] A 23-year-old woman with hereditary hemorrhagic telangiectasia wasfound in her bedroom presenting right-side hemiparesis and aphasia. Brain computed tomography angiography (CTA) showed a complete occlusion of left-medium cerebral artery (Panel A) that requiredmechanical thrombectomy.CTA revealed the typical arteriovenous malformations in the lungs(Panel B) but not in the brain or liver. A bubble contrasted echocardiography ruled out intracardiacal shunts. Furthermore, repletiondefects were found in subsegmentarial pulmonary arteries (Panel C,amplified in the inset). No thrombus was detected in lower extremity veins with Doppler-ecography, and thrombophilia screening wasnegative.