Giant circulating malignant cells spotted in feathered edge of blood film

[摘要] A 20-year-old male presented with a 4-week history of dry cough,night sweats, weight loss, and fever. Blood tests showed normocyticanemia (hemoglobin 71 g/L) and severe thrombocytopenia (platelets17 × 109/L). His blood film demonstrated leukoerythroblastosis, occasional red blood cell fragments, and giant cells in the feathered edge(Figure 1, panel A; Wright–Giemsa stain, original magnification ×400).Imaging revealed a large anterior mediastinal mass.