Plasmablastic lymphoma with MYC::IGH fusion and BCL2 rearrangement

[摘要] A 50-year-old male with history of nodal stage III diffuse large B-celllymphoma (DLBCL), refractory to R-CHOP, presented with vomiting, abdominal pain, and an umbilical mass. Abdominal computedtomography (CT) scan showed bulky retroperitoneal adenopathy andpossible bowel obstruction. Histologic examination of the umbilicalmass needle biopsy demonstrated diffuse atypical cells with medium to large nuclei, prominent central nucleoli, and eccentrically placedamphophilic cytoplasm (Figure 1, top left panel, objective 100×).