Almost Complete Response with a Single Administration 225 Ac-DOTATATE in a Patient with a Metastatic Neuroendocrine Tumor of Unknown Primary

[摘要] Neuroendocrine tumors (NETs) are being seen increasingly frequently, and the only known curative treatment method is surgical resection. Peptide receptor radionuclide therapy (PRRT) is a treatment option that the most contributes to progression-free survival and overall survival in metastatic cases.β-emitting radionuclides are traditionally used for PRRT. Nowadays, alpha particle-emitting radionuclides are being developed, with advantages in terms of very high energy and a short path length, which should theoretically show higher efficacy. In this case; in a patient with NET diagnosis who had multiple (>50) lesions in the abdomen, almost all the lesions disappeared with a single dose application. This paper aims to present a case in which we observed the efficacy of 225 Ac-DOTATATE treatment, which is an alpha treatment.

[关键词] 225Ac targeted alpha therapy;neuroendocrine tumors;peptide receptor radionuclide therapy