Clinical relevance of a newly developed endometrial receptivity test for patients with recurrent implantation failure in Japan

[摘要] Purpose To assess the clinical efficacy of personalized embryo transfer (pET) guided by a new endometrial receptivity test, ERPeak SM , in patients with recurrent implantation failure (RIF). Methods Recurrent implantation failure patients of all ages at two private Japanese clinics from April 2019 to June 2020 were retrospectively analyzed. The intervention group ( n  = 244) received pET in accordance with endometrial receptivity testing results and was compared to control group ( n  = 306) receiving standardized timing, non-personalized embryo transfer (npET). In propensity score matching analysis, the clinical pregnancy rate (CPR) and live birth rate (LBR) were compared between groups, and a subanalysis of advanced maternal age (AMA) (≥38 years old) versus non-AMA (<38 years old) patients was also conducted. Results The CPR and LBR of the pET group were significantly higher than those of the npET group (37.7% vs. 20.0%, adjusted OR: 2.64; 95%CI, 1.70–4.11, p  < 0.001 and 29.9% vs. 9.7%, adjusted OR: 4.13; 95%CI, 2.40–7.13, p  < 0.001, respectively). Furthermore, in the subanalyses, the CPR and LBR of the pET group were significantly higher than those of the npET group in both the AMA non-AMA patients. Conclusions The new ERPeak SM endometrial receptivity test is a useful alternative diagnostic tool for poor-prognosis patients, regardless of age.

[学科分类] 工业工程学

[关键词] advanced maternal age;endometrial receptivity test;personalized embryo transfer;recurrent implantation failure;window of implantation