Design and Development of Medicated Lollipop Containing Albendazole

[摘要] The present work is aimed at Design and development of medicated lollipop containing Albendazole. One of the major health problems faced by hundreds of millions of school-age children is infection by helminths, more commonly known as worms. Albendazole is used as abroad-spectrum anthelmintic. The conventional dosage forms like tablets, capsules, syrups etc are inconvenient for paediatric, geriatric, bedridden patients because of difficult to swallow tablets and capsules or unpleasant taste of drug. As a result, the demand for developing new technologies has been increasing day by day. Lollipops are defined as the flavoured medicated dosage forms intended to be sucked and held in the mouth or pharynx containing one or more medicaments usually in the sweetened base.  Medicated lollipop is designed to improve patient compliance and increase oral retention time. The lollipops were prepared by heating and congealing method using hydroxypropylmethylcelluloseK4M as polymer. Drug-excipient compatibility study was carried out using FTIR. All the formulations were subjected to various physicochemical evaluations like weight variation, hardness, drug content, friability etc. The in-vitro dissolution study of F3 was carried out by two method a) Paddle method b) flow through cell method .The in-vitro permeation  study of F3 was found to be 72.2% at 30 min. Stability study was carried out as per ICH-Guidelines (Q1A) at 25±2 o C/60±5% RH and 40±2 o C/75±5% RH . From the present study it can be concluded that addition of hydrophilic polymers yield good result to prolong oral retention time of lollipop.

[学科分类] 药学

[关键词] Medicated lollipop;Albendazole;Hydroxypropylmethylcellulose(HPMC K4M)