Formulation and Evaluation of Escitalopram Nanoparticles by Employing Cutina As Lipid

[摘要] Nanoparticles are submicron nano sized particles having the size range of about 1-100nm range. Because of their sub-microscopic size, they have unique material characteristics, and manufactured nanoparticles may find practical applications in a variety of areas, including medicine, engineering, catalysis, and environmental remediation. Escitalopram (ETP), an SSRI (selective serotonin reuptake inhibitor), and s-enantiomer of citalopram is exclusively used as an antidepressant. The drug shows extensive hepatic metabolism, reduced drug efficacy and potential side effects, which reduces its therapeutic index. So, the present study is focused on increasing the solubility and thus the bioavailability. The nanoparticles were prepared by using hot homogenization method by using Cutina as lipid, soya lecithin as lipophilic surfactant and PEG as hydrophilic surfactant. The prepared solid lipid Nanoparticles were evaluated for Drug content, entrapment efficiency and dissolution studies and stability studies and found that the Drug content ( 90.7%), Entrapment efficiency ( 86.1 %) and Drug release of ( 82.4%), Particle size( 796nm) and Zeta potential ( - 29.4mV).

[学科分类] 药学

[关键词] Escitalopram;Hot Homogenization method;Solid lipid Nanoparticles