Formulation and Evaluation of Natural Gum Based Fast Dissolving Tablet

[摘要] Current research is focused on formulation and evaluation of natural gum based fast dissolving tablet of aceclofenac by applying 32 factorial design. Direct compression method was used. Two factors as independent variable (x1)okra gum (x2) sodium saccharin glycol ate were taken with three level (+1, 0,-1) .The level two factors were selected on basis of preliminary experiments conducted and their effect on dependent variable (disintegration time ,in vitro drug release) was estimated formulated tablets were evaluated for parameters (hardness, thickness, weight variance, wetting time and water absorption ratio, disintegration time ,friability,% commutative drug release ).the software design expert (11.0) was used for gee rating experimental design ,modeling the response surface and calculating the static evaluation .The tablet parameters tests of formulation (F1 TO F 10 ) were observed within prescribe limit. DT observed in the range of 51 sec to 9 min. % cumulative drug release 0.31 % to 107.97 %. Batch F10 was observed as promising batch with DT values 46 sec.

[学科分类] 药学

[关键词] Aceclofenac;Abelmoschus esculent us mucilage powder;Fast Dissolving tablets;pharmaceutical excipients.