New Analytical Methods for the Determination of Two Gliptin Drugs In Pharmaceutical Formulations and Urine Samples

[摘要] New ion – associate complexes of the two gliptin drugs, vildagliptin and saxagliptin were precipitated with tetraiodometrcurate and ammonium reineckate and the excess unreacted metal complex was determined. New methods were given for the determination of these drugs in pure solutions, pharmaceutical formulations and urine samples using atomic absorption and atomic emission spectrometry. The drugs can be determined by the afford methods in the ranges 0.68 – 74.69 and 0.70 – 77.42 μg / ml for vildagliptin and saxagliptin, respectively.

[学科分类] 药学

[关键词] Ion-associate complexes;atomic absorption;atomic emission;pharmaceutical analysis .