Synthesis of 2-(Bis(2-chloroethyl)amino)-N-(4-((3-oxobenzofuran-2(3H)-ylidene)methyl)phenyl)acetamide Derivatives on Basis of Benzaldehydes and Acetophenones As Possible Alkylating Anticancer Agents

[摘要] A series of 2-(Bis(2-chloroethyl)amino)-N-(4-((3-oxobenzofuran-2(3H)-ylidene)methyl) phenyl)acetamide derivatives were synthesized by fusing aurones with nitrogen mustards. Aurones being synthesized by treating 4-nitrobenzaldehydes with various derivatives of 1-(2- hydroxyphenyl)ethenone. The characterization of the synthesized compounds was done by FTIR, 1H NMR and LCMS spectral studies. The titled compounds were tested for their possible anticancer activities by in vitro methods by SRB Assay. These compounds were found to exhibit a moderate anticancer activity.

[学科分类] 药学

[关键词] Aurone;nitrogen mustard;anticancer;SRB Assay using A-549 and MCF-7 Cell lines