Transdermal Drug Delivery System: A Review

[摘要] Transdermal patches are designed to deliver a therapeutically effective amount of drug across the skin membrane. In order to deliver therapeutic agents through the skin for systemic effects, the great physicochemical, morphological and biological properties of the skin are taken into consideration. Transdermal drug delivery system offers controlled release of drug substance into patient’s skin, it enables a mild blood level profile, resulting in reduced systemic side effects over the other dosage forms. Transdermal delivery is more convenient and painless technique for administration of drugs. It provides vanguard over injectables and oral route by increasing patient compliance and avoiding first pass metabolism respectively. The formation of transdermal drug delivery system (TDDS) has been one of the most innovative approaches of drug deliveries.

[学科分类] 药学

[关键词] Transdermal drug delivery system (TDDS);Transport mechanism;Permeation mechanism;Iontophoresis;Microneedles.