A Review on Nasal Drug Delivery System and General Consideration

[摘要] Nasal drug delivery system offers way of drug delivery of both topical and systemic therapies. The high permeability, high vasculature and low enzymatic environment of nasal cavity are well suitable for systemic delivery of drug molecules via nose. The despite of all the advantages of nasal drug delivery, the bioavailability of nasally administered products, especially for protein and peptide molecules, is affected by many barriers such as physiological barriers, physicochemical barriers, and formulation barriers. This review will focus on the various bioavailability barriers in nasal drug delivery and the strategies to improve the bioavailability of nasal dosage form.

[学科分类] 药学

[关键词] Barrier;Nasal Delivery;Bioavailability