The Protective Effect of Cinnamic acid on Rotenone-Induced Pseudoparkinsonism in Rats

[摘要] Background and Objectives Parkinson disease (PD) is a common neurodegenerative disease characterizedby progressive loss of midbrain dopaminergic neurons with multifactorial etiologies, including age,genetic and environmental factors. The current treatments of the disorder only reduce symptoms but donot stop the disease progression. Cinnamic acid has been shown to exert neuroprotective and antioxidanteffects in different models of neurodegenerative diseases. This study aims to investigate the effectsof cinnamic acid on pseudoparkinsonism induced by rotenone in rats.Subjects and Methods In this experimental study, 40 male rats (weight range: 160-200 g) were randomlydivided into 5 equal groups (n= 8): group 1 (rotenone 3 mg/kg/48 h for 19 days), group 2 (L-dopa 10 mg/kg/48 h for 19 days), group 3 (rotenone 3 mg/kg 48 h plus cinnamic acid 50 mg/kg/48 h for 19 days),group 4 (rotenone 3 mg/kg/48 h and cinnamic acid 100 mg/kg/48 h for 19 days), and group 5 (rotenone3 mg/kg/48 h and cinnamic acid 200 mg/kg/48 h for 19 days) . In all groups, the muscle stiffness wasmeasured by the Morpurgo method, the rate of catalepsy by rearing test, and the amount of malondialdehyde(MDA).Results According to Morpurgo test results, the mean rate of muscle stiffness was significantly lower inthe cinnamic acid 100 and 200 mg/kg groups compared to the 50 mg/kg cinnamic acid group at all timepoints. According to the rearing test results, the mean length of muscle stiffness was not significantlydifferent between the 100 and 200 mg/kg groups but was significantly different between L-dopa groupsand other groups. Regarding the MDA test, it was significantly lower in the L-dopa group than in theother three groups. Also, the MDA values in 100 mg/kg and 200 mg/kg were lower than the 50 mg/kgcinnamic acid group.Conclusion The study's results reported the effectiveness of cinnamic acid in improving muscle stiffnessand muscle weakness, which was dose-dependent. So that cinnamic acid at higher doses was moreeffective in improving these two complications. Moreover, the results reported the effect of differentdoses of cinnamic acid on the reduction of MDA.

[学科分类] 基础医学

[关键词] Pseudoparkinsonim;Cinnamic acid;Rotenone;Malondialdehyde;Rat