Comparing of The Effect of Long-Term Caffeine Consumption Combined With Aerobic Exercise on Serum Interleukin-6 Level and Body Composition in Obese Men

[摘要] Background and Objectives Caffeine is a purine alkaloid with anti-oxidant and anti-inflammatory effects.This study aims to evaluate the effect of long-term caffeine consumption and aerobic exercise on seruminterleukin-6 (IL-6) level and body composition in obese men.Subjects and Methods In this quasi-experimental study, 40 obese men (Mean age=32.8±2.74 years, bodymass index=30.98±1.37 kg/m2) were randomly divided into four Group of 10 including placebo, supplementation,placebo + exercise, and supplementation + exercise. The aerobic exercise program includedrunning for 8 weeks, 3 sessions per week, each for 25-45 minutes with an intensity of 55-85% of themaximum heart rate. The supplementation group received 500 mg caffeine daily and the placebo groupreceived 500 mg capsules of 2% maltodextrin. Blood samples were taken following 12 hours of fastingbefore and 48 hours after the last training session to measure IL-6 level. Data were analyzed using onewayANOVA and Tukey’s post hoc test. The significance level was set 0.05.Results In the exercise+supplementation and placebo+exercise groups significant decreases werereported in the serum level of IL-6 compared to the supplementation and placebo groups in thepost-test phase (P<0.05). There was also a significant decrease in body composition of groupsplacebo+exercise, exercise+supplementation, and supplementation compared to placebo group inthe post-test phase (P<0.05).Conclusion Aerobic exercise alone and in combination with long-term caffeine consumption can reduceIL-6 level and improve body composition in obese people.

[学科分类] 基础医学

[关键词] Caffeine;Aerobic exercise;Interleukin-6;body composition;Obesity