The effect of 4 weeks of resistance training on serum omentin-1 levels and metabolic factors in male diabetic rats

[摘要] Background and Objectives Omentin-1 is a new adipokine with a potential to increase insulin sensitivity,and is associated with lipid profile. There are limited studies on the effect of exercise on the serum levelof Omentin-1. The present study aims to investigate the effect of progressive resistance training (PRT) onplasma level of omentin-1 and glycemic control in diabetic male rats.Subjects and Methods In this study, 24 male Wistar rats were randomly divided into three groups: Control,diabetic, and diabetic+PRT. The training group performed a PRT program using a ladder (three daysa week, for 4 weeks). Body weight, glucose level, amentin-1 level, insulin level, and lipid profile weremeasured.Results The PRT significantly increased plasma levels of omentin-1 and triglycerides in the diabetic + PRTgroup compared to the diabetic group (P=0.017). There was no significant difference in high-density lipoprotein(F=0.318, P>0.05), low-density lipoprotein (F=0.612, P>0.05) and cholesterol (F=0.049, P>0.05)levels between the study groups.Conclusion The PRT improves omentin-1 and insulin resistance in diabetic rats.

[学科分类] 基础医学

[关键词] resistance training;Diabetes Mellitus;Omentin-1;insulin resistance