Hypertrophy of the heart - A new therapeutic target?

[摘要] Recent studies call into question the necessity of hypertrophic growth of the heart as a compensatory response to hemodynamic stress. These findings, coupled with recent progress in dissecting the molecular bases of hypertrophy, raise the prospect of suppressing hypertrophy without provoking circulatory insufficiency. In this article, we focus on signaling pathways that hold promise as potential targets for therapeutic intervention. We also summarize observations from animal models and clinical trials that suggest benefit from an antihypertrophic strategy.

[关键词] PROLIFERATOR-ACTIVATED RECEPTOR;LEFT-VENTRICULAR HYPERTROPHY;ENHANCED MYOCARDIAL-CONTRACTILITY;INHIBITS CARDIAC-HYPERTROPHY;SYNTHASE KINASE 3-BETA;IN-VIVO;MYOCYTE HYPERTROPHY;BETA(1)-ADRENERGIC RECEPTOR;PROTEIN-KINASE;GENE-TRANSFER