Cell cycle progression - New therapeutic target for vascular proliferative disease

[摘要] Entry into and progression of vascular cells through the cell cycle is considered a key event in vascular proliferative diseases. Multiple growth factors and cytokines have been found to regulate vascular cell proliferation. However, the machinery regulating cell cycle represents the final common pathway of these signaling cascades and thus provides an attractive therapeutic target for the prevention of vascular proliferative diseases. This review focuses on the current understanding of the regulation of the cell cycle machinery especially as it relates to vascular cell biology and the feasibility of targeting cell cycle for the prevention of restenosis after balloon angioplasty and bypass vein graft disease.

[关键词] SMOOTH-MUSCLE CELLS;RAT CAROTID-ARTERY;DEPENDENT KINASE INHIBITOR;TRANSFORMING GROWTH FACTOR-BETA-1;RESTENOSIS FOLLOWING ANGIOPLASTY;RENIN-ANGIOTENSIN SYSTEM;C-MYC EXPRESSION;IN-VIVO;INTIMAL HYPERPLASIA;GENE-THERAPY