Neurophyisological and Neurocognitive Endophenotypes for Schizophrenia Genetics Research

[摘要] There is growing interest in the genetic analysis of schizophrenia using endophenotypes rather than clinical diagnosis or symptom dimensions. Endophenotypes could be alternative phenotypes for the clinical phenotypes. With their intermediate and quantitative characteristics, endophenotypes could be functionally important links in the pathways between the genetic variation and clinical expression of the disorder. In this regard, the neurophysiological and neurocognitive endophenotypes used in the genetic analysis of schizophrenia have been reviewed.

[发布日期] 2008-12-01

[关键词] ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;LONG-QT SYNDROME;NEUROPSYCHOLOGICAL ENDOPHENOTYPES;PREPULSE INHIBITION;STARTLE RESPONSE;DEFICITS;LINKAGE;DISEASE