Host factors and the pathogenesis of HIV-induced disease

[摘要] The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the cellular co-receptors for HIV and the cellular tropism of different strains of virus will advance our understanding of HIV-induced pathogenesis and suggests new therapeutic and preventive strategies.

[关键词] HUMAN-IMMUNODEFICIENCY-VIRUS;TUMOR-NECROSIS-FACTOR;NF-KAPPA-B;TYPE-1 INFECTION;IMMUNE-RESPONSE;FACTOR-ALPHA;PERIPHERAL-BLOOD;HOMOSEXUAL MEN;CELL-LINE;IN-VIVO