Scar prevention: The healing touch

[摘要] Wounds made early in gestation in embryos of many species including human, heal rapidly and perfectly. Over the past number of years scientists have been probing the mysteries of this process in the hope of improving adult wound healing and perhaps even making scarless healing a reality. The evolutionary conservation of the healing mechanism means that researchers can study its basic biology easily in lab workhorses such as fruitflies and mice. Recent research hasshown that mice lacking a protein called Smad3, which is involved in inflammation, healed their skin wounds faster than normal mice. The emerging evidence leads to the idea that in wound healing, less inflammation might be better. Transforming growth factor-beta-3 (Juvista), is a new drug which has passed initial safety and efficacy trials in skin wounds.

[关键词] GROWTH-FACTOR-BETA;GRAINY-HEAD;DROSOPHILA;MICE;MORPHOGENESIS;WOUNDS;REPAIR