Selecting and maintaining a diverse T-cell repertoire

[摘要] To provide a T-cell population that will respond promptly to foreign antigen, the immune system looks inward, using the variety of self-antigens to select and maintain a diverse repertoire of receptors. A protective Immune system must include a T-lymphocyte population that is poised to respond to foreign antigenic peptides presented by self-major histocompatibility complex molecules. As the organism cannot predict the precise pathogen-derived antigens that will he encountered, the system uses the diverse array of self-peptides bound to self-major histocompatibility complex molecules, not only to select a receptor repertoire in the thymus, but also to keep naive T cells alive and 'ready for action' in the periphery.

[关键词] SINGLE MHC/PEPTIDE LIGAND;ANTIGEN RECEPTOR GENES;CLASS-II MOLECULES;ATHYMIC NUDE RATS;POSITIVE SELECTION;SELF-PEPTIDES;HISTOCOMPATIBILITY ANTIGEN;HOMEOSTATIC REGULATION;THYMOCYTE DEVELOPMENT;LYMPHOID HOMEOSTASIS