Enabling the chemistry of life (vol 409, pg 226, 2001)

[摘要] Enzymes are the subset of proteins that catalyse the chemistry of life, transforming both macromolecular substrates and small molecules. The precise three-dimensional architecture of enzymes permits almost unerring selectivity in physical and chemical steps to impose remarkable rate accelerations and specificity in product-determining reactions. Many enzymes are members of families that carry out related chemical transformations and offer opportunities for directed in vitro evolution, to tailor catalytic properties to particular functions.

[关键词] CATALYSIS;ENZYMES;DNA;SYNTHETASE;EVOLUTION;BIOSYNTHESIS;POLYKETIDE;SYNTHASE;PATHWAYS;PROTEINS