Intersection of biology and therapeutics: type 2 targeted therapeutics for adult asthma

[摘要] Asthma is a disease of reversible airflow obstruction characterised clinically by wheezing, shortness of breath, and coughing. Increases in airway type 2 cytokine activity, including interleukin-4 (IL-4), IL-5, and IL-13, are now established biological mechanisms in asthma. Inhaled corticosteroids have been the foundation for asthma treatment, in a large part because they decrease airway type 2 inflammation. However, inhaled or systemic corticosteroids are ineffective treatments in many patients with asthma and few treatment options exist for patients with steroid resistant asthma. Although mechanisms for corticosteroid refractory asthma are likely to be numerous, the development of a new class of biologic agents that target airway type 2 inflammation has provided a new model for treating some patients with corticosteroid refractory asthma. The objective of this Therapeutic paper is to summarise the new type 2 therapeutics, with an emphasis on the biological rationale and clinical efficacy of this new class of asthma therapeutics.

[关键词] TO-MODERATE ASTHMA;DOUBLE-BLIND;EOSINOPHILIC ASTHMA;UNCONTROLLED ASTHMA;AIRWAY HYPERRESPONSIVENESS;INHALED CORTICOSTEROIDS;MONOCLONAL-ANTIBODY;PERSISTENT ASTHMA;GENE-EXPRESSION;ALLERGIC-ASTHMA