Structure and function of aldopentose catabolism enzymes involved in oxidative non-phosphorylative pathways

[摘要] Platform chemicals and polymer precursors can be produced via enzymatic pathways starting from lignocellulosic waste materials. The hemicellulose fraction of lignocellulose contains aldopentose sugars, such as d-xylose and l-arabinose, which can be enzymatically converted into various biobased products by microbial non-phosphorylated oxidative pathways. The Weimberg and Dahms pathways convert pentose sugars into α-ketoglutarate, or pyruvate and glycolaldehyde, respectively, which then serve as precursors for further conversion into a wide range of industrial products. In this review, we summarize the known three-dimensional structures of the enzymes involved in oxidative non-phosphorylative pathways of pentose catabolism. Key structural features and reaction mechanisms of a diverse set of enzymes responsible for the catalytic steps in the reactions are analysed and discussed.

[发布日期] 2022-12-19

[关键词] Aldopentose;Non-phosphorylative pathways;Pentose catabolism;Aldose-1-dehydrogenase;Lactonase;Sugar acid dehydratase;Ketoglutarate-semialdehyde dehydrogenase;Aldolase