DE-FG02-05ER64001 Overcoming the hurdles of multi-step targeting (MST) for effective radioimmunotherapy of solid tumors

[摘要] The 4 specific aims of this project are: (1) Optimization of MST to increase tumor uptake; (2) Antigen heterogeneity; (3) Characterization and reduction of renal uptake; and (4) Validation in vivo of optimized MST targeted therapy. This proposal focussed upon optimizing multistep immune targeting strategies for the treatment of cancer. Two multi-step targeting constructs were explored during this funding period: (1) anti-Tag-72 and (2) anti-GD2.

[发布日期] 2009-09-21

[学科分类] 放射科、核医学、医学影像

[关键词] ANTIGENS;IN VIVO;NEOPLASMS;OPTIMIZATION;RADIOIMMUNOTHERAPY;THERAPY;VALIDATION