Engineering the Interface Between Inorganic Materials and Cells

[摘要] To further optimize cell function in hybrid ???living materials???, it would be advantageous to render mammalian cells responsive to novel ???orthogonal??? cues, i.e. signals they would not ordinarily respond to but that can be engineered to feed into defined intracellular signaling pathways. We recently developed an optogenetic method, based on A. thaliana Cry2, for rapid and reversible protein oligomerization in response to blue light. We also demonstrated the ability to use this method to channel the light input into several defined signaling pathways, work that will enhance communication between inorganic devices and living systems.

[发布日期] 2014-05-31

[学科分类] 材料科学（综合）

[关键词] materials engineering;cell-material interface;light;optogenetics