The frequency and associations of post endoscopy gastro-intestinal cancers

[摘要] This thesis investigated and examined the frequency and associations of post endoscopy gastro-intestinal cancers. Oesophagogastroduodenoscopy (OGD) and colonoscopy are the investigation of choice for diagnosing upper gastrointestinal cancers (UGIC) and colorectal cancers (CRC) respectively. Evidence suggests there are a proportion of patients who have had negative OGD or colonoscopy examinations prior to their later UGIC or CRC diagnosis. These events are commonly termed post-OGD upper gastrointestinal cancers (POUGIC) and post colonoscopy colorectal cancers (PCCRC). This body of work utilised a wide range of health data, each with its unique advantages and disadvantages. A primary care data base was used to investigate the frequency of POUGIC and its associations in the UK in a case-control study. The incidence of POUGIC and PCCRC in England was investigated with risk factors identified, provider and temporal variations examined using national hospital administration data. The incidence of POUGIC in the Midlands and its association with patient, endoscopy and endoscopist factors was investigated using regional secondary care endoscopic records with cancer registry data linkage. The findings in this body of work could be used to guide further research into reducing the incidence of POUGIC and PCCRC with the aim for earlier cancer diagnosis.

[发布机构] University:University of Birmingham;Department:Institute of Cancer and Genomic Sciences

[关键词] R Medicine;RC Internal medicine;RC0254 Neoplasms. Tumors. Oncology (including Cancer)